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10.1016/j.expneurol.2010.02.006 26 BurgessJ.FerdousiM.GosalD.BoonC.MatsumotoK.MarshallA.et al (2021)

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Furthermore, GSTs are additionally identified as regulators of cellular signaling pathways, thereby influencing cell proliferation or apoptosis (Tew and Townsend, 2012

The main culprits include: Ultraviolet and visible light exposure the strongest daily stimulator Hormonal fluctuations (pregnancy, contraceptives, thyroid changes) Inflammation from acne, eczema or injury (post-inflammatory hyperpigmentation) Ageing and genetics Certain medications or skin trauma Globally, pigmentary disorders affect a significant portion of the population, with surveys showing around half of adults reporting at least one pigmentation concern